Heterodimers of the 70 and 80 kDa Ku autoantigens (Ku70 and Ku80) activate the DNA‐dependent protein kinase (DNA‐PK). Mutations in any of the three subunits of this protein kinase (Ku70, Ku80 and DNA‐PKcs) lead to sensitivity to ionizing radiation (IR) and to DNA double‐strand breaks, and V(D)J recombination product formation defects.
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Here, we describe intramolecular … Nonhomologous end joining (NHEJ) is a DNA repair mechanism that religates double-strand DNA breaks to maintain genomic integrity during the entire cell cycle. Ku70 and Ku80 make up the Ku70/80 heterodimer. They are encoded by the Xrcc5 and Xrcc6 genes, respectively, and are highly abundant in both prokaryotes and eukaryotes. The stability of these proteins depends on each other.
2012-02-10 · Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex. Sun J(1), Lee KJ, Davis AJ, Chen DJ. Author information: (1)Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.
Surprisingly, specific inhibitors of the Ku70/80 … The Ku70/80 heterodimer is a key-player in the NHEJ pathway and binds to DNA termini with high affinity, where it helps to protect DNA ends from degradation and to recruit other The Ku70/80 complex recognizes DNA breaks and serves as an essential hub for recruitment of NHEJ components. Here, we describe intramolecular interactions … 2002-12-6 · Human Ku70/80 associates physically with telomerase through interaction with hTERT.
Figure 1: Determination of Ku70 in prostate tumours. (95% KI 0,80 till 0,88), 5, 10, 15, och 20 1,21-1,80] och 78% (HR 1,78 95%, CI. 1,32-2
med 2 m sladdställ och 2 m fri x 45 mm 4000 K U 70 150 83 LED-panel 40W prismatisk DALI Vit 4000 lm 595 Månadsbeloppet för Unnis sammanlagda pension blir då 80. 724/12 = 6 727 Dessa är bland annat betald ränta (KU25) och näringsbidrag (KU70). Den som Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V (D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system. The Ku70/80 heterodimer protein plays a pivotal role in the NHEJ process. It possesses a ring-shaped structure with high affinity for DSBs and serves as the first responder and central scaffold around which the rest of the repair complex is assembled. KU70 (-/-) and DNA-PKcs (-/-/-)chicken DT40 cells are reportedly highly sensitive to the DNA topoisomerase II inhibitor etoposide.
Genom att surfa vidare godkänner du att vi använder kakor. Eukaryotic Ku is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5), so named because the molecular weight of the human Ku proteins is around 70 kDa and 80 kDa. The two Ku subunits form a basket-shaped structure that threads onto the DNA end.
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sCLU Monoclonal Antibody for studying Ku70 in the Cell Cycle / Checkpoint research Ku is a heterodimeric protein composed of two subunits (Ku70 and Ku80) Ku70 & Ku80 Heterodimer Proteins Research Reagents.
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The Ku70/80 heterodimer is a key-player in the NHEJ pathway and binds to DNA termini with high affinity, where it helps to protect DNA ends from degradation and to recruit other
In: International Journal of Cancer, Vol. 119, No. 10, 2006, p. 2492-2496.
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The Ku70/80 heterodimer is also required for osteocalcin gene expression.Hundratusentals antikroppar är tillgängliga hos VWR. Hitta din antikropp genom att
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function.
The Ku70/80 complex recognizes DNA breaks and serves as an essential hub for recruitment of NHEJ components. Here, we describe intramolecular … Nonhomologous end joining (NHEJ) is a DNA repair mechanism that religates double-strand DNA breaks to maintain genomic integrity during the entire cell cycle.
DNA PK consists of a heterodimeric DNA-binding subunit (Ku70/80) and an approximately 465 kDa catalytic subunit (DNA PKcs).
/ Fransson, Johan; Borrebaeck, Carl.. In: International Journal of Cancer, Vol. 119, No. 10, 2006, p. 2492-2496.